In order to explore the deep uranium metallogenic environment and reveal the deep geological characteristics in Youdong area of Renhua county, Guangdong Province, the paper introduces the construction of Changjiang No.1 Scientific Deep Drilling and the application of several construction techniques. By analyzing the service life and drilling efficiency of the drill bit, we found S95 series of deep hole drilling bits had better effect than S75 series and analyzed the reasons .By analyzing the existing problems of tradition techniques and using the hydraulic impactor, the pure drilling efficiency was increased as high as 5%., which provides the basis for improving the process in the future; By improving the angle of hydraulic pipe tong , the top angle reach 10 degrees and suitable for inclined hole drilling; By taking screw motor directional drilling technology for the first time, the deviation distance of drilling hole was successfully corrected to the contract requirement. After the whole hole lost circulation, the top leakage drilling technology was used to finish the hole, which made a breakthrough in deep top leakage drilling technology in Zhuguang area. The Changjiang No.1 Scientific Deep Drilling was designed to be 1 500 m, and the final finished depth was 1 709.34 m which lasted 142 actual construction days. The construction process was continuously optimized and adjusted and encountered the deepest economic uranium ore in China. The screw directional rectification measures adopted in this hole provided a new construction technology for the drilling about 1 500 m deep inclined hole in Youdong area of Renhua county, Guangdong Province. The Other technique study and applied process measures provided reference for the similar projects.