Based on the analysis of lithology and uranium content，four layers were determined as the the prospecting objects. The main target layer in Erlian Basin is the upper member of Saihan Formation （K1 s2），the important layer is the lower member of Saihan Formation（K1 s1），the concerned layer is the second segment of Tenggeer formation（K1 t2） and the considered layer is the Erlian Formation（K2 e）. An overall analysis on the conditions of uranium metallogenic process was conducted from uranium source-structure evolution-sedimentary covers-transformation. It was believed that the upper member of the Saihan Formation mainly developed paleo-valleys along the long axis of each sag，forming paleo-valley-type uranium mineralization，which was controlled by the paleo-valley，the low-sag in the center of the depression and the epigenetic alteration；The lower member of the Saihan Formation and the second member of the Tengger Formation mainly developed fan delta sedimentary system along the slope of the basin margin，forming phreatic-interlayer oxidation zone type uranium mineralization，which was controlled by uranium source，delta sedimentary system and epigenetic alteration；The Erlian Formation mainly developed lacustrine sedimentary system in the central part of Errennao depression，and formed sedimentary diagenetic uranium mineralization，which was controlled by uranium source and the largest lake flooding surface in Erlian period；At the same time，it was pointed out that large-scale uranium mineralization was developed in Erlian Basin，which can be roughly divided into three stages: sedimentary diagenesis at 99～78 Ma，epigenetic main mineralization at 67～37 Ma and reformation superimposed epigenetic at 25～8 Ma. On this basis，the prospecting direction was pointed out by the type of strata. The prospecting work in Erlian basin should be focused on Ulanqab and Manit depression，radiating three major depressions，namely Chuanjing，Tengger and Unit，with overall consideration and reasonable deployment，which has great prospecting potential.