In this paper，the data of 1:50 000 210po survey in the Qingzhangshan mineralization cluster area was used to study the characteristics of 210Po anomaly and its application effect on the exploration of granite type uranium deposit in North Guangdong. By referring to the geological characteristics，the measured 210po data were processed with the method of trend surface analysis and other statistics. The results showed that trend surface analysis can eliminate the interference of geological background on the extraction of 210Po anomaly with different uranium content. The integrated application of 210Po with ground gamma spectrometry，radon survey and AMT can reach good effect in searching blind ore body in the deep of granite areas，The position simultaneously respondent to the anomaly peak of various methods is the location of ore-bearing fracture or the uranium ore body. Economic benefit ore bodies were exposed by the later drilling in the abnormal area of 210Po survey，which suggest that the 210Po method is of great guiding significance in the exploration of granite-type uranium deposits in North Guangdong.